Morphology, size distribution and release behavior of microfluidic-fabricated cellulose acetate nanoparticles containing omeprazole
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1Department of Polymer, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
2Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
The objective of this work is to develop a novel pH-sensitive cellulose acetate nanoparticles containing omeprazole as an acid labile drug using microfluidics emerging technique. These nanoparticles are synthesized by nanoprecipitation process. The FE-SEM and DLS results showed that the optimum sample with a minimum mean nanoparticles diamter of 47±4 nm and polydispersity index of 0.09 ± 0.01 was attained by adjusting the flow rate ratio of polymer to non-solvent phases of 0.05. Also, the surface charge value of the sample was obtained to be approximately -46 mV, which indicated a high colloidal stability of the nanoparticles besides their indendancy for aggregation. Eventually, the in-vitro drug release study by UV-Vis spectrophotometry exhibited the omeprazole liberation of less than 10% from the cellulose acetate nanoparticles in an acidic medium. This leads to the drug bioavailabilty enhancement at physiological pH for oral prescription uses.
Microfluidics; Cellulose Acetate; Omeprazole; nanoparticle; Surface charge; Drug release; Bioavailability