Controlled release of Ceftriaxone sodium drug loaded in chitosan nanoparticles: preparation and kinetic modeling study
Volume Title: 1
Ferdowsi University of Mashhad
In this work, Ceftriaxone sodium-loaded chitosan nanoparticles (CTX-loaded CNPs) were synthesized using the ionotropic gelation method. The size of nanoparticles was obtained 265 nm using DLS analysis. The entrapment efficiency of CTX inside chitosan nanoparticles was found to be 79% according to UV/vis spectrophotometry at λ=274 nm. The drug release study for free CTX and CTX-loaded CNPs was performed at pH=7.4 and, a more controlled release was observed in the case of nanoparticles. Kinetic modeling of drug release data at pH=7.4 was carried out based on zero-order, first-order, Higuchi, and, Korsmeyer-Peppas models. The results confirmed a diffusion mechanism for drug release based on the Korsmeyer-Peppas model in which swelling and dissolution of chitosan is negligible.