Electrospun Acellular Heart ECM for Cardiac Tissue Engineering
Volume Title: 1
Authors
1Dept Chem Petroleum Eng
2Department of Chemical & Petroleum Engineering, Sharif University of Technology,
3School of Chemical Engineering, College of Engineering, University of Tehran, Iran
4Department of Chemical & Petroleum Engineering, Sharif University of Technology
Abstract
Electrospun nanofiber is one of the promising alternatives for use in tissue engineering and drug delivery due to its controllable characteristics. However, choosing an appropriate biomaterial for a specific tissue regeneration plays a significant role in fabricating functional tissue-engineered constructs. In this study, acellular calf heart extracellular matrix (ECM) has been investigated as a potential biomaterial to be electrospun for cardiac tissue engineering. The acellular calf heart was electrospun in combination with poly vinyl pyrrolidone (PVP), gelatin (Gel) and polycaprolactone (PCL). The obtained fibers were aligned, uniform, and bead free. After fabrication, the scaffolds were cross-linked in glutaraldehyde vapor to become mechanically stronger and dissoluble in the aqueous environments. Considering surface topography, biocompatibility, and hydrophilicity, the fabricated hybrid electrospun ECM/PVP fibers can be proposed as a biomimetic scaffold for heart tissue engineering applications.
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