Using electrocoagulation for the removal of propofol from the aqueous solutions; Application of response surface as an experimental design method
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1Chemical Engineering Faculty, Sahand University of Technology
2Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3Nikukari Eye Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
In the present work, the experimental data designed by response surface method for the investigation the removal of propofol as a toxic drug from the hospital wastewater by using electrocoagulation technique. A central composite design (CCD) and ANOVA were applied for the design and analysis of the experimental data, respectively. The quadratic model was derived by employing design-expert (v.10) software and the sum square error as the objective function which must to be minimized. propofol concentration was also measured by two various methods including HPLC and UV-Vis to show the accuracy of each methodology. To the best of our knowledge is to indicate that UV-Vis can be used as a low cost method with negligible difference with HPLC analysis to detect the propofol in the aqueous solutions. Effect of the important variables encompassing pH of solution, electrode spacing, dosage of electrolyte and voltage was studied, Results showed that the interaction between the pH-volatge and voltage-electrolyte dosage had the remarkable effect on the removal efficiency of propofol. The maximum removal efficiency was calculated to be 91.5%.