Production of Solid Lipid Nanoparticles loaded with Trametes versicolor Exopolysaccharides
Volume Title: 1
1دانشجوی کارشناسی ارشد- دانشگاه تهران
2Life Science Engineering Department, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
3گروه مهندسی علم زیستی- دانشکده علوم و فنون نوین دانشگاه تهان
4Chemical Engineering Department, Faculty of Petroleum and Petrochemical Engineering, Hakim Sabzevari University, Sabzevar, Iran
5گروه مهندسی علوم زیستی، دانشکده علوم و فنون نوین، دانشگاه تهران، تهران، ایران
A variety of drug delivery systems have been developed, among them nanoparticles are more widely considered, because they have easier production methods. Lipid nanoparticles are made from solid lipids or a combination of solid and liquid lipids. Solid lipid nanoparticles (SLNs) are made using lipids known to be safe and not melting at room temperature. The size of these particles is between 50 and 1000 nm. Polysaccharides are the strongest fungal compounds that have anti-tumor, antioxidants and immune enhancement properties. In this study, we optimized the production of SLNs loaded with Trametes versicolor exopolysaccharides (EPS). In optimum conditions (drug/lipid: 0.17, surfactant: 12%) the size of SLNs loaded with EPS is 286.3 nm with -40.9 mv zeta potential. This study showed that surfactant and drug/lipid have a significant effect (p < 0.05) on nanoparticle size and zeta potential. Due to the therapeutic properties of T. versicolor, the use of nanoparticles loaded with it’s polysaccharides improves it’s availability and effectiveness.