Separation of plasma from blood using a dielectrophoresis-assisted microfluidic device: a computational fluid dynamics study
Volume Title: 1
Authors
1Department of Chemical and Petroleum Engineering, Sharif University of Technology, Azadi Street, Tehran, Iran
2Sharif University of Technology, Faculty of Chemical and Petroleum Engineering
Abstract
This paper presents a microfluidic device using dielectrophoresis to separate plasma from blood. The device comprises a main channel, five lateral channels, and four microelectrodes. The performance of the system is evaluated by directing the plasma through the lateral channels and blood cells through the main channel. Simulations were performed for three different concentrations of red blood cells. It is found that the separated plasma purity increases with increasing the applied voltage to the microelectrodes. In addition, increasing the flow rate increases the required applied voltage for attaing desired separation. Finally, it is observed that a plasma purity of 100% with the plasma separation of 65% could be obtained at the flow rate of 0.01 mL/min and the applied voltage of 107 V with the applied voltage frequency of 1 MHz.
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