Fabrication of polymeric nano-fibers containing Curcumin for wound covering application
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Authors
1Chemical Engineering Department, Science and Research Branch, Islamic Azad University, Tehran , Iran
2Chemical Engineering Department - Faculty of Engineering - Science and Research Branch , Tehran - Islamic Azad University
3Chemical Engineering Department, Faculty of Engineering, Science and Research Branch,Islamic Azad University, Tehran, Iran
Abstract
Electrospinning is one of the most important methods for producing nano-fibers, which is the easiest, least expensive and most efficient method. It uses electric field to produce fine fibers which their diameter can reduce to nanometers, and a wide range of polymers are used through this method. In this work electospinning of polycaprolactone (PCL) in a mixed solvent of Acetic acid (AA)/chloroform in a mixed solvent of Acetic acid (AA)/Chloroform (CL) with 50:50 volumetic mixing ratio plus Curcumin was studied. The size of PCL fibers obtained was in the range of 200 nm to 1.38 μm with either bead on string or smoth fiber morphology. The effect of solution concentrations (5% , 10 %) and applied voltages (7.5 kv to 14 kv) on the formation, morphology, and structure of nanofibers was also investigated. SEM micrographs showed successful production of PCL nanofibers with different solvents. With increasing the polymer concentration, the average diameter of nanofibers increases. Furthermore, increasing applied voltage resulted in fibers with larger diameter. It was also observed that the solution concentration exponentially affected fiber size. The fiber size also increased with an increase in solution flow rate. Moreover, the applied voltage and the collecting distance had maximal effect on PCL fiber size.
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