Electrospinning Acellular Calf Heart Extracellular Matrix for Cardiac Tissue Engineering
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Authors
1Dept Chem Petroleum Eng
2Department of Chemical & Petroleum Engineering, Sharif University of Technology,
34Department of Chemical & Petroleum Engineering, Sharif University of Technology
4Department of Chemical & Petroleum Engineering, Sharif University of Technology
Abstract
Electrospun nanofiber is one of the promissing scaffolds for use in tissue engineering and drug delivery due to its controllabale characteristics. However, choosing an appropriate biomaterial for a specific tissue regeneration plays a significant role in fabricating functional tissue-engineered constructs. In this study, acellular calf heart extracellular matrix (ECM) has been investigated as a potential biomaterial to be electrospun for cardiac tissue engineering. The acellular calf heart was electrospun in combination with poly(vinyl pyrrolidone) (PVP). The obtained fibers were aligned, uniform, and bead free. After fabrication, the scaffolds were cross-linked in glutaraldehyde vapor to become mechanically stronger and dissoluble in the aqueous environments. The fabricated electrospun ECM/PVP fibers migth be considered as an appropriate biomimetic scaffold for heart tissue engineering applications.
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