Solubility of Valsartan in Supercritical Carbon Dioxide: Experimental Measurement and Correlation
1Faculty of Chemical, Petroleum and Gas Engineering, Semnan University, Iran.
2Nuclear fuel cycle research, iran atomic energy organization.
In this study, the solubility of valsartan in supercritical carbon dioxide (SC-CO2) was measured within pressures ranging from (12 to 24) MPa and at various temperatures (308.15, 318.15 and 328.15) K. Subsequently, five semi-empirical equations include of Chrastil, Kumar & Johnston, Mendez-Santiago & Teja, del Valle & Aguilera, and Sung & Shim have been used for determining the solubility of valsartan in SC-CO2. In fact, in this work, the experimental data were obtained using the static flow apparatus and were correlated using these semi-empirical equations. In this study, the results obtained from these semi-empirical equations were in good agreement with our experimental data.